BEGIN:VCALENDAR VERSION:2.0 PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4// BEGIN:VEVENT UID:20251219T083642EST-3126tfbvub@132.216.98.100 DTSTAMP:20251219T133642Z DESCRIPTION:Progress in advancing our understanding of biological systems i s\nlimited by their sheer complexity\, the cost of laboratory materials\na nd equipment\, and limitations of current laboratory technology.\nComputat ional and mathematical modeling provides ways to address\nthese limitation s through hypothesis generation and testing without\nexperimentation - all owing researchers to analyze system structure\nand dynamics in silico and\ , then\, design lab experiments that yield\ndesired information about phen omena of interest.  These\nmodels\, however\, are only as accurate and com plete as the data used\nto build them.  Currently most models are construc ted from\nquantitative experimental data.  However\, since accurate\nquant itative measurements are hard to obtain and difficult to adapt\nfrom liter ature and online databases\, new sources of data for\nbuilding models need to be explored.  In my research\, I design\nmethods for building and exec uting computational models of cellular\nnetworks based on qualitative expe rimental data\, which is more\nabundant\, easier to obtain\, and reliably reproducible.  Such\nexecutable models allow for in silico perturbation\, simulation\, and\nexploration of biological systems.  In this talk\, I wil l\npresent two general strategies for building and executing Petri\nnet-ba sed models of biochemical networks.  Both have been\nsuccessfully used to model and predict the dynamics of signaling\nnetworks in normal and cancer cell lines\, rivaling the accuracy of\nexisting methods trained on quanti tative data.\n \n DTSTART:20091014T183000Z DTEND:20091014T193000Z LOCATION:McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1Y6\, 3655 pr omenade Sir William Osler SUMMARY:Bioinformatics Seminar\, Dr. Derek Ruths\,Deriving Executable Model s of Biochemical Network Dynamics from Qualitative and Semi-Quantitative D ata URL:/channels/event/bioinformatics-seminar-dr-derek-ru thsderiving-executable-models-biochemical-network-dynamics-qualita-111320 END:VEVENT END:VCALENDAR