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UID:20251212T230501EST-61539v6IpS@132.216.98.100
DTSTAMP:20251213T040501Z
DESCRIPTION:Dr. Robert Nadon\n海角社区\nAssociate Professor\, Depa
 rtment of Human Genetics\nPrincipal Investigator\, 海角社区 and G
 enome Quebec\nInnovation Centre\n\n鈥淒etection of Rare Biological Events in
  High-Throughput\nScreens鈥漒n聽\n聽\nPrimary high-throughput screens (HTS) ar
 e used to identify rare\nbiological events among a large number of inactiv
 e features.聽\nThis needle-in-the-haystack problem is made even more diffic
 ult\nwhen attempting to discover weak effects in contexts such as\nfragmen
 t-based screens\, which examine low potency\nlow-molecular-weight ligands 
 that bind to biologically significant\nmacromolecules\, RNAi screens in wh
 ich weak but genuine phenotypes\ncan be caused either by partial knockdown
  of a gene with a strong\neffect or a strong knockdown of a gene with a we
 ak effect\, and in\npharmaceutical screens for maximizing discovery of new
  chemical\nseries or scaffolds for drug development.聽 Current standard\nHT
 S practice unfortunately performs poorly in these circumstances\ndue to me
 asurement uncertainty.聽 Inherent random variability\nof the assays places 
 limits on hit discovery and reproducibility\;\nsystematic errors (bias) in
 troduced by procedures\, equipment\, and\nmaterials\, can both mask biolog
 ical activity and give the\nappearance of activity when there is none.聽 I 
 will present\nrecent work from my lab which shows how study design\, diagn
 ostic\ngraphical methods\, normalization\, and statistical inference tests
 \ncan substantially improve detection of weak effects in primary HTS\nscre
 ens.聽 An Excel add-in software package implementing the\nmethods is availa
 ble.\n聽\nMandatory for Graduate Students\n
DTSTART:20110505T200000Z
DTEND:20110505T200000Z
LOCATION:McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1Y6\, 3655 pr
 omenade Sir William Osler
SUMMARY:Biochemistry Seminar - Dr. Robert Nadon
URL:/channels/event/biochemistry-seminar-dr-robert-nad
 on-174091
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