Judith Mandl
Dr. Mandl鈥檚 research focuses on investigating (1) immunodeficiencies that arise from defects in cell migration and impair T cell immunity; (2) specific challenges for immune cell motility in tissues, such as cellular crowding and mechanical forces; and (3) the architecture of the T cell receptor repertoire and the importance of sub-threshold T cell receptor interactions with self-peptide MHC in lymphoid organs in determining T cell effector potential. She is also fascinated by, and has written about, immune responses to viruses in their reservoir hosts, such as primates and bats. Mandl鈥檚 team takes a highly multi-disciplinary, quantitative and systems-driven approach, implementing state-of the art microscopy, sequencing, and quantitative analysis tools to link individual cell behaviour with cell-population and organismal-level outcomes.
Research Areas of Interest:
- Immunology
- Host-pathogen interactions
- Immunodeficiencies
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