BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4//
BEGIN:VEVENT
UID:20260411T234401EDT-0674C2UZ4v@132.216.98.100
DTSTAMP:20260412T034401Z
DESCRIPTION:\nSupported by the generosity of the Killam Trusts\, The Neuro'
 s Killam Seminar Series invites outstanding guest speakers whose research 
 is of interest to the scientific community at The Neuro and º£½ÇÉçÇø Univers
 ity.\n\n\nRegister Now\n\nTo watch online\, click here\n\nHost: Heidi McBr
 ide\n\n\nTurning the oxygen and vitamin dials\n\nAbstract: Oxygen deprivat
 ion (hypoxia) and excess (hyperoxia) are both toxic to humans. Oxygen depr
 ivation contributes to 3 of the 5 leading causes of mortality in developed
  nations -- heart attack\, stroke\, and respiratory failure. On the other 
 hand\, hyperoxia is toxic to nearly all organisms and contributes to the p
 athology of ischemia-reperfusion injury\, mitochondrial disease and hypero
 xic lung injury. However\, the molecular mechanisms underlying hypoxia and
  hyperoxia toxicity remain unknown. By deciphering these mechanisms\, we s
 trive to nominate novel therapeutic candidates. Our recent work highlights
  such mechanisms of hyperoxia toxicity and the cycle of damage caused by d
 estabilization of specific iron-containing protein complexes. While small 
 molecules and biologics are the most common forms of therapy\, we believe 
 we have uncovered a new mode of treating metabolic disorders. We now hope 
 to extend our findings to additional inborn errors of metabolism\, as well
  as more common metabolic disorders\, including aging and age-associated d
 amage.\n\nIsha Jain\n\nAssociate Professor\, Biochemistry and Biophysics\,
  UCSF\, USA\n\n \n\nIsha received her undergraduate degree in Chemical and
  Physical Biology from Harvard University. There\, she worked in the lab o
 f Erin O’Shea on bacterial chromosome segregation. Subsequently\, she join
 ed the Harvard-MIT Program in Health Sciences and Technology. During her P
 hD\, she worked in the   labs of Vamsi Mootha and Warren Zapol\, where she
  discovered that hypoxia could serve as a therapy for mitochondrial disord
 ers. This work led to a Phase 1 clinical trial. Isha began as a UCSF Sandl
 er Faculty Fellow and then joined the Gladstone Institutes and UCSF in 202
 1. She has received the NIH Early Independence Grant\, Searle Scholar Awar
 d\, Klingenstein-Simons Award\, Mallinckrodt Award\, TRDRP New Investigato
 r Award\, AFAR Junior Faculty Award\, Hillblom Start-Up Grant\, Keck Medic
 al Research Grant\, and Arc Innovation Investigator Award.\n
DTSTART:20260317T200000Z
DTEND:20260317T210000Z
LOCATION:de Grandpre Communications Centre\, The Neuro\, Montreal Neurologi
 cal Institute\, CA\, QC\, Montreal\, H3A 2B4\, 3801 rue University
SUMMARY:Killam Seminar Series: Turning the Oxygen and Vitamin Dials
URL:/neuro/channels/event/killam-seminar-series-turnin
 g-oxygen-and-vitamin-dials-371565
END:VEVENT
END:VCALENDAR