Molecules to re-sensitize bacteria to itaconate produced in macrophages as a new treatment for infections.

Team:ÌýKarine Auclair and AndéanneÌýLupien

Stage:ÌýDiscover, Develop and AMR Winner

Cohort:Ìý2024 and 2025

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Oscillating device for non-invasive correction of Bruxism

Team:ÌýNatalie Reznikov and Vinay Ashok KumarÌý

Stage:ÌýDiscover

Cohort:Ìý2025

Advancing bubble continuous positive airway pressure (bCPAP), a non-invasive respiratory support therapy for preterm infant lung development.

Team:ÌýAmanda Gross, Emily Campbell and Wissam Shalish

Stage:ÌýDiscover

Cohort:Ìý2025

The traditional medical approach is "one size fits all", leading to resource inefficiency, extended delays, and prolonged treatment for patients. Bit Healix tackles this problem by leveraging genetic information and the power of AI to personalize diagnostic treatment, so patients can receive the right care the first time.

Team:ÌýYannis Trakadis, Bill Qi, Sameer Sardaar

Stage:ÌýDiscover

Cohort:Ìý2024

A first of its kind device for real-time detection of viruses and bacteria​, offering on-site diagnostics in milliseconds. Patholyzer is a smaller, portable Nano-digital inline holographic microscope used to identify and measure airborne pathogens. This project has enormous potential to fight against antimicrobial resistance (AMR), which poses one of the largest threats to human health in the coming century.

Team:ÌýDevendra Pal, Parisa Ariya, and Robert Panetta

Stage:ÌýDevelop and AMR Winner

Cohort:Ìý2024

BioOptic™ seeks to offer a quick and easy way to measure one’s intra-abdominal pressure (IAP) which is shown to influence spinal stability and hence linked to back pain. Specifically, the device design and methods employed will be refined towards improving the accuracy, reliability, and usability of the device to get fully ready for market.

Team:ÌýMark DriscollÌý

Stage:ÌýDevelop

Cohort:Ìý2022

Activation of peripheral pain sensing neurons (nociceptors) is central to the experience of pain, and several chronic pain conditions are caused by the sensitization of nociceptors to mechanical stimuli, including osteoarthritis and rheumatoid arthritis pain. We have identified an ion channel expressed in nociceptors and involved in sensing mechanical pain which represents a potential therapeutic target in chronic inflammatory pain. Determining a small molecule inhibitor to specifically target this ion channel would prevent the pain signal and may have valuable therapeutic potential in OA and RA patients, as well as other inflammatory pain conditions. Watch this video to learn more.

Team:ÌýReza SharifÌý

Stage:ÌýDiscover

Cohort:Ìý2022

INVICARE develops an innovative biomedical technology to address infections around implants, with a two-fold approach to include prevention and more effective treatment. The company's core technology is a proprietary two-dimensional nanocrystalline hydrogel; the outcome of seven years of collaborative research between º£½ÇÉçÇø scientists and researchers from Harvard Medical School and the University of Montreal.

Team:Ìýº£½ÇÉçÇø ResearchersÌý

Stage:ÌýDeploy

Cohort:Ìý2022

Conventional water filtration techniques rely on high amounts of chemicals used in large volume tanks that leaves behind a toxic sludge that can later pose serious environmental problems related to its disposal. The project proposes a low-cost, easy-to-manufacture solution that utilizes fibrous materials to act as a filtration mechanism. The solution would greatly simplify treating water, and would be more adaptable to both large and small-scale filtration systems.

Team:ÌýNathalie Tufenkji

Stage:ÌýDevelop

Cohort:Ìý2023

Few would doubt the value of shock-absorbing materials such as those found in safety helmets or automobile bumpers. However, in practice they are disposable items that are thrown away after each major collision, thus creating significant environmental impact. The team is developing a bio-mimetic material that can reform after impact, enabling objects to withstand repeated impacts, which can lengthen the service life of the item, and reduce the volume of material that ends up in landfills.

Team:ÌýHamid AkbarzadehÌý

Stage:ÌýDiscover

Cohort:Ìý2023